The association between TNP2 gene polymorphisms and Iranian infertile men with varicocele: A case-control study
نویسندگان
چکیده
منابع مشابه
Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele
BACKGROUND Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observ...
متن کاملAssociation study of six SNPs in PRM1, PRM2 and TNP2 genes in iranian infertile men with idiopathic azoospermia
BACKGROUND Histones are replaced by protamines to condensate and package DNA into the sperm head during mammalian spermatogenesis. Protamine genes defects have been reported to cause sperm DNA damage and male infertility. OBJECTIVE In this study relationship among some protamines genes family SNPs include PRM1 (C321A), PRM2 (C248T) and TNP2 (T1019C), (G1272C), (G del in 1036 and 1046 bp) were...
متن کاملP-131: The Study of Nitric Oxide Synthase 3 (NOS3) 4a4b Gene Polymorphism in Iranian Infertile Men with Varicocele
Background Varicocele is an abnormal dilation and tortuosity of veins of pampiniform plexus that drains the testis and causes an important change in semen.This abnormality is often one of the most common risk factors for male infertility. The aim of this study was to investigate the relationship between nitric oxide synthase 3 (NOS3) 4a4b (rs61722009) gene polymorphism, as a common genetic fact...
متن کاملMitochondrial Genetic Variation in Iranian Infertile Men with Varicocele
Objective Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observe...
متن کاملP-213: Mutation Analysis of Mitochondrial ND4L Gene in Iranian Infertile Men with Varicocele
Background: Varicocele is the abnormal tortuosity and dilatation of the veins of the pampiniform plexus within the spermatic cord. Varicocele-related pathology is suspected in infertility as it leads to elevated temperatures in the scrotum and testes, which has a deleterious effect on spermatogenesis. In Varicocele patients, ROS production is enhanced and total antioxidant capacity (TAC) is red...
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ژورنال
عنوان ژورنال: International Journal of Reproductive BioMedicine
سال: 2019
ISSN: 2476-3772,2476-4108
DOI: 10.18502/ijrm.v17i8.4821